Friday 21 August 2026 | The Daily Papule

No. 51 · 21 Aug 2026Friday 21 August 2026: 35 papers from 20 journals← Thursday’s edition Saturday’s edition →

Rezpegaldesleukin treatment of moderate-to-severe atopic dermatitis (REZOLVE-AD)

final results from the 16-week induction period of an international, double-blind, placebo-controlled, randomised phase 2b study.

ConclusionOver the 16-week induction period, rezpegaldesleukin treatment resulted in significant and clinically meaningful improvements across multiple clinical endpoints, including the primary endpoint of EASI percentage change from baseline, in comparison with placebo. Rezpegaldesleukin had a clinically favourable adverse event profile in adult patients with moderate-to-severe atopic dermatitis, supporting its further development as a novel Treg-enhancing biological treatment.

Silverberg JI, Rosmarin D, … senior author Warren RBThe Lancet

Full abstract Read at publisher(opens in a new tab)

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JAADRCT
Comparison of efficacy and safety of oral corticosteroid mini pulse versus oral tofacitinib in stabilization of active vitiligo
A 24-week randomized controlled assessor-blinded clinical trial with evaluation of serum IL-6 as a surrogate marker.
Waghmare P, Singh S, … senior author Sankanagoudar SJournal of the American Academy of Dermatology
Derm TherRCT
EP262, an MRGPRX2 Antagonist for the Treatment of Atopic Dermatitis
Results From the Phase 2 Randomized EASE Study.
Dehn S, Cooper D, … senior author Bissonnette RDermatology and Therapy
JCMSSystematic reviewGuideline
Immune Checkpoint Inhibitors in Advanced Sebaceous Carcinoma
A Systematic Review, Biomarker Analysis, and Clinical Recommendations.
Abdul-Rahman NH, Joerg L, … senior author Pugliano-Mauro MAJournal of Cutaneous Medicine and Surgery

LancetLaboratory research
Expanding regulatory T cells to treat atopic dermatitis.
Valenzuela F, Munoz MDThe Lancet
BJDObservational study
Over-the-counter Products and Complementary Therapies in Childhood Atopic Dermatitis
a National Survey of Pharmacists.
Dours L, Plasson A, … senior author Leducq SBritish Journal of Dermatology
BJDLaboratory research
Beyond fibroblast activation
expanding the role of the AREG-EGFR axis in keloid pathogenesis.
Li Z, He Y, … senior author Zhao SBritish Journal of Dermatology

JEADVObservational study
Factors influencing quality of life in hidradenitis suppurativa
Data from 1188 patients.
Pascual JC, Garcias-Ladaria J, … senior author Grau-Pérez MJournal of the European Academy of Dermatology and Venereology
JEADVObservational studyLetter
GLP-1 and GLP-1/GIP agonists in psoriasis
A real-world cohort study on healthcare resource usage.
Hill MA, Treichel A, Cooper KDJournal of the European Academy of Dermatology and Venereology
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Research on Epidemiology of Metal Sensitization in Japan.
Iwahashi Y, Okusa T, … senior author Nakada TDermatitis
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Immediate In Vivo Human Skin Responses to Picosecond Laser Irradiation
A Histological, Ultrastructural, and Theoretical Study.
Omatsu J, Sakai T, … senior author Shimojo YLasers in Surgery and Medicine
J Cosmet Derm
Ultrapulse Carbon Dioxide Laser in the Treatment of Secondary Scar Lesions of Acne Conglobata
A Novel, Minimally Invasive Method
Xu Y, Yang M, … senior author Wang LJournal of Cosmetic Dermatology
Contact Derm
Assessment of Content and Release of Nickel, Cobalt and Lead in Metallic and Rhinestone Nail Charms in the United States.
Ames E, Schaffer T, … senior author Hamann CRContact Dermatitis
Australas J DermObservational study
Patient Perspectives on Dupilumab Therapy for Atopic Dermatitis
Experiences, Expectations and Treatment Impact.
Abu-Ghazaleh N, Ross G, Morgan VAustralasian Journal of Dermatology
J Cosmet DermObservational study
Longitudinal Imaging Patterns Following an Imaging-Guided Dual-Axis Picosecond Nd
YAG Protocol for Facial Hyperpigmentation
Kwon SJ, Bang JYJournal of Cosmetic Dermatology
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Maternal and Infant Skin Microbiome Synchrony and Divergence
A Longitudinal Study of Skin Microbial Ecology and Early-Life Assembly.
Wilborn D, Constantinou A, … senior author Blume-Peytavi UExperimental Dermatology
J Cosmet DermObservational study
Dermatological, Trichological and Quality of Life Consequences of GLP-1 Receptor Agonist-Mediated Weight Loss
A US Cross-Sectional Survey
Olivero JW, Paturi J, … senior author Zheng QJournal of Cosmetic Dermatology
J DermatolObservational study
The Impact of Molluscum Contagiosum on Depression, Anxiety and Quality of Life in Children.
Artik A, Atas H, … senior author Durak MJournal of Dermatology
Arch Derm Res
Psychological and socioeconomic factors associated with depression and anxiety among patients with psoriasis
Al-Gawahiri M, Godding LTH, … senior author Seyger MMBArchives of Dermatological Research
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Nail Involvement in Refractory Pediatric Alopecia Areata: A Duration-Dependent Finding.
Türkay A, Uzunçakmak TK, Serdaroğlu SSkin Appendage Disorders
AJCDReview
Cutaneous Aging in Skin of Color: A Narrative Review.
Vipulaguna N, Abdulkader F, … senior author Rodrigues MAmerican Journal of Clinical Dermatology
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Modern Therapies for Discoid Lupus Erythematosus: A Narrative Review.
Jonnalagadda A, Richmond RL, … senior author Vesely MDDermatology and Therapy
JAAD ReviewsReview
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A distinct entity requiring a dedicated clinical framework
Kazmi A, Patel RD, … senior author Netravali IAJAAD Reviews
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Pediatric alopecia areata phenotypes
Toward a clinically actionable framework
Chajecki A, Modanlo N, … senior author Netravali IAJAAD Reviews
BMJ
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Fuentes MI, Joshi TPJournal of the American Academy of Dermatology
JAADLetter
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Islam RK, Falgout LM, … senior author Haas CJJournal of the American Academy of Dermatology
BJD
Does the higher asthma prevalence in preterm children with atopic dermatitis indicate a distinct allergic pathway?
Kaplan FBritish Journal of Dermatology
Am J DermpathCase report
Coexistence of Acantholytic Dyskeratosis and Epidermolytic Hyperkeratosis in a Single Cutaneous Lesion
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Sánchez-Arjona M, Lecona M, Requena LAmerican Journal of Dermatopathology
Am J DermpathCase report
Multifocal Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, Presenting on Face and Chest
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Panagiotidis M, Gerdemeli I, … senior author Sotiriou EAmerican Journal of Dermatopathology
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Granular Cell (Granular-type) Fibrous Papule of the Face
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Vance PK, Martin HLAmerican Journal of Dermatopathology
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Skin Oncology.
Grechin C, Ormond P, … senior author Boggs JClinical and Experimental Dermatology
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Letter: Facial Airborne Allergic Contact Dermatitis Associated with E-Cigarette Vaping.
Demichele G, Sbarra G, … senior author Foti CDermatitis
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The First Human Case of Dermatophilus congolensis Dermatitis in Japan.
Matsumoto S, Kondo A, … senior author Mabuchi TJournal of Dermatology
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