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AJCDSystematic review

Sex Hormones in Psoriatic Disease: A Systematic Review.

ConclusionFluctuations in estrogen and progesterone associated with female life stages, as well as reduced androgen levels in males, may influence disease activity. PsO often improves during pregnancy but may worsen postpartum or around menopause, while altered prolactin signaling may also be involved. Evidence for PsA and hormone-based interventions remains limited and inconsistent. Clinicians should consider closer monitoring during major hormonal transitions, while further mechanistic and clinical validation is needed to clarify the role of sex hormones in psoriatic disease.

Cai Y, Xiao H, … senior author Xiao YAmerican Journal of Clinical Dermatology

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