Monday 24 August 2026 | The Daily Papule

Efficacy and Safety of Yellow Light Monotherapy Versus Yellow Light Combined With 20% Vitamin C for the Treatment of Melasma

A Single-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Study

ConclusionCombined 20% vitamin C plus yellow light phototherapy yielded statistically superior melasma improvements relative to yellow light monotherapy, though the absolute reduction in mMASI was modest. The combination regimen preserved skin barrier function and exhibited good tolerability.

Du D, Liu X, … senior author Jiang XJournal of Cosmetic Dermatology

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