J Cosmet DermMeta-analysisSystematic review
Oral Probiotics for Improving Skin Hydration, Elasticity, Transepidermal Water Loss, and Wrinkle Reduction in Adults
A Systematic Review and Meta-Analysis of Randomized Controlled Trials
ConclusionOral probiotic supplementation may be associated with skin hydration and barrier function improvement in healthy adults with low-to-moderate certainty evidence. Effects are most consistent for TEWL reduction. High heterogeneity, limited numbers of outcome-specific trials, frequent industry sponsorship, and potential publication bias warrant cautious interpretation. Future large-scale RCTs with standardized strains, dosing, and long-term follow-up are needed.
Nezhadpour AS, Hemadi E, … senior author Makvandi MJournal of Cosmetic Dermatology