J Derm TreatMeta-analysisSystematic review
Efficacy differences of biologic agents targeting different pathways in obese patients with psoriasis
a systematic review and meta-analysis.
ConclusionObesity may be associated with reduced response to biologics in psoriasis, although the PASI90 result was affected by publication bias and became non‑significant after correction. The impact appeared to differ by class, with significant effects for IL‑17 and IL‑12/23 inhibitors in subgroup analyses, but these findings require confirmation in larger studies. Weight status should be considered as one of multiple factors when selecting biologics, but current evidence does not support treatment selection based solely on obesity.
Zhou W, Xu Z, … senior author Pan XJournal of Dermatological Treatment