A Preliminary Report of Real-World Clinical Experience With Cold-Crosslinked Hyaluronic Acid Fillers

BACKGROUNDThough data from clinical studies can inform real-world application of new hyaluronic acid (HA) injectables, the eventual role of a given product in clinical practice is difficult to predict. Here, a panel of expert injectors share their experience with cold-crosslinking process (Cold-X Technology) HA fillers Evolysse Form (EVLF) and Evolysse Smooth (EVLS; Symatese, Chaponost, France).

METHODSTwenty-one expert dermatologists and facial plastic surgeons with an average of 24 years of experience (range 13–40 years) were provided with EVLF and EVLS to treat real-world patients in their practices. All participants completed a survey on product use and overall experience and six participants participated in a 2-h roundtable where case studies were discussed.

RESULTSEVLF was most often used in the cheeks (16/21), NLF (15/21), chin (13/21), and marionette lines (12/21), and EVLS in the marionette lines (15/21), oral commissures (15/21), and lips (13/21), using a range of different injection techniques. Seventy-six percent (16/21) of participants indicated that they were likely or very likely to incorporate EVLF and EVLS into their regular filler portfolio.

CONCLUSIONSExperience with EVLS and EVLF was positive: both are versatile, do not necessitate changes to existing workflows, and are able to achieve efficient outcomes in clinical practice.

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