BMJMeta-analysisSystematic review
Antihistamines for atopic dermatitis (eczema)
systematic review and network meta-analysis of randomised trials.
ConclusionAmong patients with atopic dermatitis, adding H1 antihistamines probably results in a clinically unimportant reduction in atopic dermatitis severity and itch severity, and may not reduce sleep disturbance or atopic dermatitis exacerbations. First generation agents increase cognitive impairment and may increase treatment discontinuation because of adverse events. Cognitive impairment risk differs among second generation agents. These findings provide evidence against routine antihistamine use in atopic dermatitis management and will inform updated clinical guidelines.
Chu AWL, Wen A, … senior author Chu DKBMJ