Microcystic Adnexal Carcinoma-like Neoplasm in a Patient With POT1 Mutation.

A 72-year-old man with a history of multiple cancers, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), presented to the dermatology clinic for a regularly scheduled full-body skin examination and subsequently was diagnosed with microcystic adnexal carcinoma (MAC). He previously had been referred to a medical geneticist and was found to have a POT1 (protection of telomeres 1) mutation. While a connection between melanoma and POT1 mutations has been established, further research may clarify the relationship between POT1 mutations and specific skin cancer susceptibility.

Abstract from PubMed