Platelet-Rich Plasma Versus Hyaluronic Acid and Vitamin C With Microneedling in the Treatment of Atrophic Acne Scars: A Comparative Study

BACKGROUND AND AIMAcne is a chronic inflammatory disease of the pilosebaceous units. Inflammatory acne may result in various kinds of scars, which can have a substantial influence on a patient's social and relationship life. The treatment of acne scars is challenging. To achieve optimal cosmetic results, a multimodal approach is required for scar treatment. The study evaluated the effectiveness and safety of microneedling with non-crosslinked hyaluronic acid and vitamin C versus platelet-rich plasma with microneedling for treatment of atrophic acne scars.

METHODSThis study included 34 patients (17–43 years) with atrophic acne scars. Dermapen was applied bilaterally, with platelet-rich plasma on the right side and non-crosslinked hyaluronic acid plus vitamin C on the left, over four sessions at three-week intervals.

RESULTSAccording to Goodman and Baron's qualitative acne scar grading system, both sides showed a significant improvement after treatment (p = 0.005, p < 0.0001 for each group). However, the response was significantly higher on the left side (vitamin C and hyaluronic acid) compared to the right side (PRP).

CONCLUSIONSWe conclude that Dermapen with PRP or hyaluronic acid plus vitamin C improved acne scars, with better results for hyaluronic acid and vitamin C.

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