Atypical Lentiginous Melanocytic Proliferations Case Series

Relationship to Type II Dysplastic Nevi and Lentiginous Melanoma.

Daruish M, De Ryck E, Gadeyne L, Lemahieu J, Loontiens S, Van Der Meulen J, Haspeslagh M, Bastian BC, Taibjee S

Journal of Cutaneous PathologyIn the feed 18 Aug 2026, published online 18 Aug 2026, issue 2026 Aug 18, added to PubMed 18 Aug 2026

Topics: Skin cancer & tumors Melanoma & moles Dermatopathology Older adults

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Abstract

A recent study described a distinctive subset of dysplastic nevi in older patients, genetically characterized by non-BRAFV600E driver mutations and frequent TERT promoter mutations. It has been proposed that these lesions overlap with the so-called lentiginous dysplastic nevi of the elderly. We explore this relationship in a series of 24 atypical lentiginous melanocytic proliferations, correlating with ex vivo dermoscopy, as well as immunohistochemical and molecular findings. We also discuss the utility of the MPATH-Dx tool to improve consensus for such lesions.

Abstract from PubMed

PMID 42609158 · DOI 10.1111/cup.70198