Combined Hyaluronic Acid and Collagen Injections for Perioral Rejuvenation

BACKGROUNDThe perioral region, a critical facial aesthetic subunit, undergoes age-related changes addressed primarily through dermal fillers. Optimal rejuvenation requires tailored approaches integrating anatomical precision, filler physicochemical properties, and standardized aging assessments.

OBJECTIVETo prospectively compare hyaluronic acid (HA)-collagen combination therapy against monotherapies for perioral rejuvenation using protocol-guided aging evaluations and personalized strategies.

METHODSNinety female patients with perioral aging were randomized equally into three groups (Dec 2022–Dec 2023): Group A (HA alone), Group B (HA-collagen), and Group C (collagen alone). Treatments were customized using baseline Comprehensive Perioral Aging Scale (CPAS) scores. Outcomes were assessed via CPAS and Global Aesthetic Improvement Scale (GAIS) posttreatment, at 3 months, and 6 months.

RESULTSGroup B demonstrated statistically superior improvements in CPAS and GAIS versus monotherapy groups at all intervals (p < 0.05). The combination regimen achieved optimal tissue support, lifting effects, and aesthetic outcomes, with sustained benefits at 6-month follow-up. Baseline characteristics showed no intergroup differences.

CONCLUSIONProtocol-guided HA-collagen synergy produces enhanced perioral rejuvenation compared to single-agent therapies, offering improved structural support and longevity of aesthetic corrections. This randomized trial validates personalized CPAS-based combination approaches for age-related perioral changes.

Abstract from Crossref