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Derm Surg

Dermal Fillers in Skin of Color

Safety Considerations, Cultural Perspectives, and Patient-Centered Approaches.

Nwaopara AU, Alexis AF, Burgess CM

Dermatologic SurgeryIn the feed 8 Oct 2026, published online 9 Oct 2026, issue 2026 Oct 09, added to PubMed 8 Oct 2026

Topics: Cosmetic, lasers, scars & woundsSkin of color

Abstract

BACKGROUNDPatients with skin of color make up a growing share of aesthetic dermatology practice, yet evidence guiding filler treatment in this population remains limited.

OBJECTIVETo review the evidence on dermal filler treatment in patients with skin of color, emphasizing safety, treatment planning, and patient-centered care.

METHODS AND MATERIALSA narrative review of PubMed/MEDLINE was performed, focusing on filler safety and efficacy in Fitzpatrick skin types (FST) IV-VI, biologic characteristics of skin of color, and population-specific aesthetic considerations.

RESULTSHyaluronic acid fillers have the strongest evidence base in higher Fitzpatrick phototypes; biostimulatory fillers, particularly calcium hydroxylapatite, show favorable safety data, although evidence remains limited for poly-l-lactic acid. Key considerations include increased risk of postinflammatory hyperpigmentation, differences in recognizing vascular occlusion, and a theoretical, not clinically observed, predisposition to hypertrophic scarring and keloid formation. Treatment goals are often shaped by patient preferences regarding ethnic preservation and facial identity.

CONCLUSIONDermal filler treatment in patients with skin of color can be performed safely and effectively when guided by an understanding of melanin-rich skin biology, population-specific aging patterns, and patient-defined aesthetic goals; additional studies in higher Fitzpatrick phototypes are needed.

Abstract from PubMed

PMID 42847967 · DOI 10.1097/DSS.0000000000005383