Temporal Filler Injection for Lifting Purposes

BACKGROUND AND AIMVolume loss in the temples, which is caused by facial aging, is not aesthetically pleasing. Non-invasive or less invasive methods have become more popular among patients and physicians. Therefore, the present systematic review and meta-analysis aimed to determine the effectiveness of injecting various temporal fillers for lifting purposes.

METHODSA search for relevant articles was conducted without time limits until June 2025 in the international databases PubMed, EMBASE, and Web of Science. The research question was developed using the Population, Intervention, Comparison, Outcome (PICO) approach to evaluate whether different dermal fillers are effective and safe in patients requiring temporal fossa augmentation. Data analyses were conducted using the meta-analysis packages in STATA/MP version 17.

RESULTSSubgroup meta-analysis showed consistent effectiveness across study designs and filler types. Hyaluronic acid and calcium hydroxyapatite fillers demonstrated high effectiveness in improving temporal volume loss, with no significant differences observed between filler categories. The overall findings indicated high rates of aesthetic improvement based on the Global Aesthetic Improvement Scale (GAIS). Meta-regression analysis suggested a significant association between injection volume and treatment effectiveness. The most commonly reported complications were mild and temporary, including edema, bruising, tenderness, erythema, and swelling at the injection site.

CONCLUSIONHyaluronic acid and calcium hydroxyapatite dermal fillers are effective and safe for improving temporal volume loss, with a significant association between injection volume and treatment efficacy. Further large-scale studies are needed to refine treatment protocols and optimize outcomes.

Abstract from Crossref