Global Research Landscapes in Keloid Treatment

BACKGROUNDKeloid treatment is a pressing challenge in clinical practice. We aim to comprehensively summarize the knowledge structure, research topics, and research trends.

METHODSThis study retrieved articles published between 1995 and 2025 from the Science Citation Index Expanded within the Web of Science Core Collection. Additionally, clinical trials indexed in PubMed were selected to evaluate progress in clinical research. Using bibliometric analysis tools and methods, such as VOSviewer, Scimago Graphica, and CiteSpace, we systematically explored the current research landscape.

RESULTSChina has the most significant number of articles, and the Chinese Academy of Medical Sciences and Peking Union Medical College are the most productive institutions. Bayat, A, is the most prolific author. Co-citation clustering analysis identified research clusters encompassing molecular pathway analysis, comprehensive management and clinical guidelines, pathogenesis and fibroblast research, genetic susceptibility, synergistic drug delivery, photodynamic therapy, and novel compound therapies. Keyword burst analysis highlights the field's comprehensive advancement toward precision targeting, evidence-based medicine, and renewed understanding of disease essence.

CONCLUSIONSOverall, this study indicates that keloid treatment focuses on precision targeting and systemic management, with frontiers expanding to delivery systems, molecular biomarkers, extracellular vesicles, metabolic reprogramming, and evidence-based management centered on guidelines and quality of life. Novel and combined treatment approaches require further exploration.

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