Microporous Annealed Particle Wound Matrix for Post-Mohs Defects

BACKGROUNDPost-Mohs surgical wounds may be painful, slow to heal, and prone to scarring. Comparative data for advanced wound care biomaterials in this setting are limited.

OBJECTIVEThe aim of this study was to evaluate the safety of a flowable, synthetic, microporous annealed particle (MAP) wound matrix versus hydrocolloid dressing and explore effects on pain, wound healing, and scarring.

MATERIALS AND METHODSIn this multicenter randomized study, a flowable synthetic MAP wound matrix was applied immediately after surgery and compared with a hydrocolloid dressing (control). The primary endpoint was safety. Exploratory endpoints included pain, Wound Bed Score, time to granulation, time to closure, and scarring at 6 months.

RESULTSForty patients were randomized to receive the wound matrix (n = 26) or control (n = 14). The primary safety endpoint was met. Pain was low in both groups and numerically lower in the matrix group. The matrix group achieved a Wound Bed Scoreof 12 or greater 14 days earlier than control. Granulation and closure times were similar. Scarring scores were significantly better in the matrix group (p = .0027).

CONCLUSIONThe MAP wound matrix was safe, did not delay healing, improved early wound bed quality, and reduced scarring versus standard of care.

Abstract from PubMed