Pilomatricomal Horn With Confirmed CTNNB1 Mutation

Pilomatricoma is a benign adnexal neoplasm of matrical follicular differentiation, typically arising in the dermis or subcutis. CTNNB1 gene mutations are well recognized in pilomatricomas. Herein, we describe a rare epidermal-based pilomatricomal lesion that clinically presented with a cutaneous horn, previously reported in the literature as pilomatricomal horn. We have also identified a CTNNB1 mutation by next-generation sequencing in our case, supporting its relationship with pilomatricoma.

Abstract from PubMed