Efficacy and Tolerability of a Multi-Targeted Anti-Acne Regimen Incorporating Salicylic Acid, Prebiotics, and Zinc PCA

INTRODUCTION AND OBJECTIVESAcne vulgaris is a multifactorial inflammatory skin disorder that affects youths and adults, often with coincident barrier disruption and dysbiosis of the microbiome surface. The primary objective of this study was to assess the effectiveness and tolerability of a 30-day multi-targeted dermocosmetic regimen shown to improve acne-prone skin while maintaining skin barrier integrity.

MATERIALS AND METHODSThis 30-day clinical study was conducted on 20 volunteers with acne-prone skin. Participants followed an 8-product cosmetic regimen for 30 days. clinical parameters (scoring of pores visibility, seborrhoea, erythema, dryness and lesions) have been evaluated by dermatologists in conjunction with instrumental measurements of skin hydration (Corneometer CM 825) and sebum levels (Sebumeter SM 815). Subjective evaluations were collected through self-assessment questionnaires. Statistical analyses were performed using paired t-tests and Wilcoxon signed-rank tests (p < 0.05).

RESULTSAfter 30 days, there were significant decreases in sebum (−9.1%), erythema, seborrhoea, pores visibility (p < 0.05), and inflammatory (23%) and non-inflammatory lesion counts (32%). Moreover, skin hydration increased (+6.2%, p < 0.01). Subjective assessments revealed high participant satisfaction regarding both product efficacy and skin feel.

CONCLUSIONThe dermocosmetic regimen led to significant improvements in acne-related parameters and skin hydration; these findings support a multi-mechanical approach towards the clinical management of acne. Further studies are recommended with a larger sample size and extended study duration, incorporating more frequent or daily monitoring to better capture treatment dynamics and improve the robustness of the findings.

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