Yellow nail syndrome.
Wetstone RA, Sloan B
Clinics in DermatologyIn the feed 26 Jul 2026, published online 26 Jul 2026, issue 2026 Sep-Oct, added to PubMed 26 Jul 2026
Topics: NailsSkin signs of systemic disease
Abstract
Yellow nail syndrome (YNS) is a rare disorder defined by the triad of yellow nail discoloration, lymphedema, and respiratory tract disease. Only two of the three signs should be present to diagnose YNS; however, this can be challenging as patients often do not exhibit all three signs concurrently. The association between YNS and malignancy has led to the hypothesis that YNS may be paraneoplastic. Treatment may include oral vitamin E for nail discoloration, serial thoracenteses for pleural effusions, and compression garments along with bandaging for lymphedema.
Abstract from PubMed
PMID 42503338 · DOI 10.1016/j.clindermatol.2026.07.025