Growth Assessment in Children Under 12 Years With Moderate-to-Severe Atopic Dermatitis Included in the PEDISTAD Observational Registry.

BACKGROUND/OBJECTIVEThe multifactorial disease burden of moderate-to-severe atopic dermatitis (AD) may affect children's growth. We report height, weight, and body mass index (BMI) of children under 12 years old with moderate-to-severe AD in comparison to the general population.

METHODSThis was a cross-sectional analysis of enrollment data from PEDISTAD, a global real-world observational study of pediatric patients < 12 years old with moderate-to-severe AD.

RESULTSAmong the 1329 children with moderate-to-severe AD, 72% of male children 5 to < 12 years were below the 50th percentile for height, as were 53% of females in this age group. In contrast, the weight of children 5 to < 12 years was above the 50th percentile in 56% of males and 52% of females, resulting in above-average BMI values. In the 0 to < 5 years old age groups, height and weight were above the 50th percentile for 59% and 50% of female children, and 52% and 42% of male children, respectively.

CONCLUSIONSThis real-world observational study showed in children 5 to < 12 years old with moderate-to-severe AD that the average height was lower than the US 50th percentile, with a more pronounced reduction in male children. Additionally, higher weight and, as a result, higher BMI were observed in the children included in this analysis.

TRIAL REGISTRATIONClinicalTrials.gov identifier: NCT03687359.

Abstract from PubMed