Immediate and Long-Term Clinical Efficacy of a Novel Topical Next Generation Hydrator

BACKGROUNDThe ability of the skin to retain moisture decreases with age. The next generation hydrator, HCH, is a novel topical cosmetic serum developed to provide immediate and long-term improvements in skin hydration by supporting natural levels of biohumectants.

AIMSThis open-label, single-center, proof-of-concept, clinical usage study assessed the efficacy and tolerability of HCH for improving skin hydration.

METHODSParticipants with mild to severe facial dryness applied HCH twice daily for 12 weeks. Investigator-assessed clinical grading, tolerability parameters, FACE-Q scales, participant self-assessments, and instrumentation measurements were conducted at baseline, immediately post-application, and at Weeks 1, 2, 4, 8, and 12.

RESULTSThe study enrolled 30 participants (aged 24–74 years, 97% women, and Fitzpatrick skin types I–V). Significant improvements were observed in investigator-assessed clinical grading of dewy hydrated skin, dryness, roughness, and radiance immediately post-application (p < 0.0001) and throughout the study. Instrumentation measurements showed significant improvements in global epidermal hydration and skin barrier function, immediately post-application and at Week 12 (p < 0.0001), as well as an increase in dermal hydration at Week 12. Participants reported high self-perceived effectiveness on 4 separate FACE-Q scales, including looking 3.2 years younger after 12 weeks of use. Most participants (97%) were highly satisfied with HCH at Week 12. Mean scores for irritability parameters were < 1 (none to mild) at all visits.

CONCLUSIONSHCH delivered significant immediate and long-term improvements in skin hydration, resulting in more dewy, hydrated skin. Participants reported high overall satisfaction on the FACE-Q validated scales. HCH was well tolerated.

Abstract from Crossref