The Effect of GLP-1 Receptor Agonists on Hidradenitis Suppurativa

Hidradenitis suppurativa (HS), or acne inversa, is a chronic and inflammatory skin disease characterized by painful nodules and abscesses. The pathogenesis involves immune dysregulation, metabolic disturbances, and hormonal influences. Glucagonlike peptide 1 receptor agonists (GLP-1 RAs) are antidiabetic medications with anti-inflammatory properties and effects on weight reduction, which may be beneficial in HS management. Our objective was to systematically review the literature on the efficacy and safety of GLP-1 RAs in the treatment of HS. Three publications met the inclusion criteria. Preliminary evidence suggests that GLP-1 RAs may be an effective adjunct therapy for HS, especially in patients with obesity and metabolic syndrome. Larger controlled studies are warranted to confirm these findings and establish clinical guidelines.

Abstract from PubMed